Can I install roll-up update 6 directly on 2012 r2 scvmm RTM? Have you seen any issues if you skip the previous roll-ups?

Ideally, the latest roll-up should include all the previous fixes too? 

If i have deployed new scvmm 2012 R2 RTM, can i directly deploy roll-up 6? 

Or, should i start from U1-2-3-4-5 and then 6? Are there are any known issues if you skip directly to the latest?

There are not many articles describing the sequence to follow for the rollups.